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Moritoh Y, Takeuchi K, Asakawa T, Kataoka O, Odaka H (2009) The dipeptidyl peptidase-4 inhibitor alogliptin in combination with pioglitazone improves glycemic control, lipid profiles, and increases pancreatic insulin content in ob/ob mice

It likely reflects the threshold at which GLP-1 receptor activation becomes clinically significant, with the associated gastric motility changes that cause nausea

Now, they are reshaping the landscape of obesity treatment and metabolic health with impacts that go far beyond the scale

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